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Item number: Cay45255-1

A dimeric tyrphostin EGFR inhibitor (IC50 = 0.4 µM), selective for EGFR over the Bcr-Abl fusion proteins p210 and p185 and wild-type c-Abl (IC50s = 44, >100, and >100 µM, respectively, for the human proteins), inhibits EGFR autophosphorylation (IC50 = 3.3 µM), inhibits EGF-dependent proliferation of HER-14...

Keywords:	Tyrphostin 537, Tyrphostin AG 537, (2E,2'E)-N,N'-1,3-propanediylbis[2-cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Application:	Dimeric tyrphostin EGFR inhibitor
CAS	140674-77-7
MW:	448.44 D

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