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Item number: Cay20116-1

ML-281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM for purified, recombinant STK33), a kinase whose downregulation is toxic to KRAS-dependent cancer cell lines. It has 700- and 550-fold selectivity for STK33 over PKA and Aurora B kinase, respectively. It is also selective over 81 other kinases...

Keywords:	N-[2-(3,4-dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
Application:	STK33 inhibitor
CAS	1404437-62-2
MW:	389.5 D

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ML281

Item number: TGM-T3423-100mg

Description: ML281, a potent and selective STK33 inhibitor, exhibits an IC50 of 14 nM. Target: Serine Protease. Smiles: CC(C)c1ccc(NC(=O)c2cccs2)c(c1)-c1nc2ccccc2[nH]c1=O. References: Spoonamore J et al. National Center for Biotechnology Information (US), 2010-2011 Dec 16.,www.ncbi.nlm.nih.gov/pubmed/23658944

Application:	STK33 inhibitor
CAS	1404437-62-2
MW:	389.47 D

From 30.00€ *

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