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EPZ005687
Item number: Cay13966-5
EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases...
| Keywords: | 1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carbo... |
| Application: | Lysine methyltranferase EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.7 D |
From 115.00€
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EPZ005687
Item number: LKT-E6396.1
A potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme EZH1.
| Keywords: | EPZ-005687,... |
| Application: | EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.67 D |
From 79.00€
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