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VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
Item number: TGM-T7944-100mg
Description: VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM). Target: PI3K, Autophagy. Smiles: CC(C)(O)CNc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccncc2)n1. References: Honda A , Harrington E , Cornella-Taracido I , et al. Potent, Selective, and...
| Keywords: | PIK-III analogue |
| Application: | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3, VPS34) inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.47 D |
From 57.00€
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VPS34-IN-19
Item number: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Keywords: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Application: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
From 142.00€
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