3 products were found matching "1380288-87-8"!
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Pinometostat
Item number: TGM-T3099-10mg
Description: Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor (Ki=80 pM). Pinometostat has antitumor activity and can be used in experiments to study a variety of leukemia treatments. Target: Histone Methyltransferase. Smiles:...
| Keywords: | EPZ-5676 |
| Application: | DOT1L inhibitor |
| CAS | 1380288-87-8 |
| MW: | 562.71 D |
From 34.00€
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EPZ5676
Item number: Cay16175-1
DOT1L is a non-SET domain containing methyltransferase whose function is important for the transcriptional activation of certain genes, DNA damage repair, and cell cycle regulation. DOT1L is known to play an essential role in MLL-rearranged leukemias, and thus has emerged as a drug target for these leukemias....
| Keywords: | 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofura... |
| Application: | DOT1L inhibitor |
| CAS | 1380288-87-8 |
| MW: | 562.7 D |
From 61.00€
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EPZ-5676
Item number: LKT-E6398.5
EPZ-5676 is an inhibitor of DOT1L histone methyltransferase (HMT) that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells with MLL gene translocations, EPZ-5676 displays cytotoxicity, in similar animal models, this compound induces tumor regression without toxicity.
| Application: | DOT1L inhibitor |
| CAS | 1380288-87-8 |
| MW: | 562.71 D |
From 240.00€
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