Description: ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold. Target: HDAC. Smiles: N(C1(CC1)C2=CC=CC=C2)C=3N=CC(C(NO)=O)=CN3. References: Jochems J, et al Antidepressant-like properties of novel HDAC6-selective...

ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of alpha-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility...