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(S)-Crizotinib
Item number: Cay31114-1
(S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1, IC50 = 72 nM). It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells. It inhibits proliferation in a panel of 14 cancer cell lines...
| Keywords: | 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Application: | MTH1 inhibitor |
| CAS | 1374356-45-2 |
| MW: | 450.3 D |
From 50.00€
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(S)-crizotinib
Item number: TGM-T6357-100mg
Description: (S)-crizotinib (ent-crizotinib) (IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib. Target: DNA/RNA Synthesis, Apoptosis, MTH1. Smiles: C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl. References: Huber KV, et al. Nature. 2014 , 508(7495), 222-227.
| Keywords: | ent-crizotinib |
| Application: | MTH1 inhibitor |
| CAS | 1374356-45-2 |
| MW: | 450.34 D |
From 31.00€
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