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Item number: Cay43595-10

PF-5274857 is a smoothened receptor (Smo) antagonist. It binds to Smo (Ki = 4. nM) and inhibits transcription of Gli1 in mouse embryonic fibroblasts (MEFs, IC50 = 2. nM). In vivo, PF-5274857 inhibits tumor growth and induces tumor regression in a medulloblastoma mouse allograft model when administered at doses less...

Keywords:	1-[4-(5'-chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1- piperazinyl]-3-(methylsulfonyl)-1-propanone
Application:	Smo antagonist
CAS	1373615-35-0
MW:	436.96 D

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PF-5274857

Item number: TGM-T5465-100mg

Description: PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh...

Keywords:	PF-5274857 freebase
CAS	1373615-35-0
MW:	436.96 D

From 30.00€ *

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