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X-396
Item number: Cay44938-1
X-396 is an inhibitor of anaplastic lymphoma kinase (ALK) and MET (IC50s = 3,000 nM). X-396 (25 mg/kg) reduces tumor growth in a lung cancer mouse xenograft model using NCI H3122 cells, which express a gain-of-function EML4-ALK fusion protein. Formal Name:...
| Keywords: | Ensartinib,... |
| Application: | ALK / MET inhibitor |
| CAS | 1370651-20-9 |
| MW: | 561.44 D |
From 48.00€
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Ensartinib
Item number: TGM-T37585-100mg
Description: Ensartinib (X-396) is a potent dual ALK/MET inhibitor with IC50 values of <0.4 nM for ALK and 0.74 nM for MET. Target: Others. Smiles: C(=O)(N1C[C@@H](C)N[C@@H](C)C1)C2=CC=C(NC(=O)C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=N3)C=C2. References: Lovly CM, et al. Insights into ALK-driven cancers revealed...
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1370651-20-9 |
| MW: | 561.44 D |
From 374.00€
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