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PF-05221304
Item number: TGM-T9209-100mg
Description: PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis. Target: Acetyl-CoA Carboxylase. Smiles: O=C1CC2(CC3=C1N(C(C)C)N=C3)CCN(C(=O)C=4C=C(N=C(OC)C4)C5=CC=C(C(O)=O)C=C5)CC2. References: Ross T T , Crowley C...
| Keywords: | Clesacostat, R 6238,, STAT5 Inhibitor III, NSC 170984 |
| Application: | Targets acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15] (ACACA) |
| CAS | 1370448-25-1 |
| MW: | 502.56 D |
From 86.00€
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PF-05221304
Item number: Cay36856-1
PF-05221304 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 12.4 and 8.7 nM, respectively). It inhibits de novo lipid synthesis (IC50 = 61 nM) and increases fatty acid oxidation in primary human hepatocytes. PF-05221304 reduces the accumulation of triglycerides composed of de novo-derived fatty...
| Keywords: | Clesacostat,... |
| Application: | Acetyl-CoA carboxylase (ACC1/ACC2) inhibitor |
| CAS | 1370448-25-1 |
| MW: | 502.6 D |
From 111.00€
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