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Item number: TGM-T4200-10mg

Description: Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin...

Keywords:	AHU377 calcium salt, AHU-377 (hemicalcium salt)
Application:	Neprilysin inhibitor
CAS	1369773-39-6
MW:	861.06 D

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AHU377 (calcium salt)

Item number: Cay21473-10

AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in...

Keywords:	Sacubitril, (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid, 4-ethyl...
Application:	Neprilysin inhibitor
CAS	1369773-39-6
MW:	430.5 D

From 94.00€ *

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