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E7046
Item number: TGM-TQ0025-10mg
Description: E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. Target: Prostaglandin Receptor. Smiles: C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O. References: Diana I. Albu, et al. EP4 Antagonism by E7046 diminishes...
| Application: | EP4 antagonist |
| CAS | 1369489-71-3 |
| MW: | 483.4 D |
From 48.00€
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E7046
Item number: Cay19673-10
E7046 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 13.5 nM). It inhibits PGE2-induced activation of pro-tumor type 2 macrophages and prevents PGE2-induced suppression of T cell proliferation in isolated human peripheral blood monocytes (PBMCs) when used at concentrations ranging from...
| Keywords: | 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid |
| Application: | EP4 antagonist |
| CAS | 1369489-71-3 |
| MW: | 483.4 D |
From 61.00€
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