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Senexin A
Item number: TGM-T5673-100mg
Description: Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively. Target: CDK. Smiles: N#Cc1ccc2ncnc(NCCc3ccccc3)c2c1. References: Porter D C , Farmaki E , Altilia S , et al. Cyclin-dependent kinase 8 mediates...
| Application: | Cdk8 inhibitor |
| CAS | 1366002-50-7 |
| MW: | 274.32 D |
From 31.00€
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Senexin A
Item number: Cay30291-1
Senexin A is an inhibitor of cyclin-dependent kinase 8 (Cdk8, IC50 = 0.28 µM). It also inhibits cyclin-dependent kinase inhibitor p21WAF1-induced reporter expression in reporter assay using HT-1080 p21-9 cells (IC50 = 0.68 µM). Senexin A (2.5 µM) prevents 17beta-estradiol-induced increases in expression of mRNA...
| Keywords: | 4-[(2-phenylethyl)amino]-6-quinazolinecarbonitrile |
| Application: | Cdk8 inhibitor |
| CAS | 1366002-50-7 |
| MW: | 274.3 D |
From 49.00€
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