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Item number: TGM-T15619-100mg

Description: JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies. Target: GluR. Smiles: Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1. References: Conde-Ceide S,et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator...

Keywords:	VU 0409551
Application:	mGluR5 positive allosteric modulator
CAS	1363281-27-9
MW:	352.36 D

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VU0409551

Item number: Cay18042-1

VU0409551 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5). It induces calcium mobilization in HEK293 cells expressing human mGluR5 (EC50 = 260 nM). It is selective for mGluR5 over mGluR1-4 and mGluR6-8 at 10 µM. VU0409551 reverses amphetamine-induced hyperlocomotion in rats...

Keywords:	JNJ-46778212, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-methanone
Application:	mGluR5 positive allosteric modulator
CAS	1363281-27-9
MW:	352.4 D

From 44.00€ *

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