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Item number: TGM-T4523-100mg

Description: TP-3654, a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM). Target: Pim. Smiles: CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1. References: Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas....

Application:	Pim kinase inhibitor
CAS	1361951-15-6
MW:	418.46 D

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TP-3654

Item number: Cay29571-5

TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively). It inhibits 19 additional kinases, including PI3Kalpha, PI3Kgamma, and PI3Kdelta, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1...

Keywords:	trans-alpha,alpha-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-cyclohexanemethanol
Application:	Pim kinase inhibitor
CAS	1361951-15-6
MW:	418.5 D

From 78.00€ *

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