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Item number: Cay13888-1

SR 9186 is an inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 0.011 µM). It is highly selective for CYP3A4 over CYP3A5 (IC50 = 33 µM). SR 9186 inhibits metabolism of midazolam to 1'-hydroxy midazolam, testosterone to 6beta-hydroxy testosterone, and vincristine to vincristine M1 in isolated human liver...

Keywords:	N-(4'-cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl]-urea
Application:	Selective CYP3A4 inhibitor
CAS	1361414-26-7
MW:	430.5 D

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