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Item number: Cay29459-1

LDC-1267 is a TAM family kinase inhibitor (IC50s = 5, 8, and 29 nM for Mer, Tyro3, and Axl, respectively). It is selective for TAM family kinases over a panel of 456 kinases at 1 µM, but does inhibit Met, Aurora B, LCK, and Src (IC50s = 35, 36, 51, and 338 nM, respectively). It inhibits suppression of proliferation...

Keywords:	N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
Application:	TAM family kinase (Mer, Tyro3, Axl) inhibitor
CAS	1361030-48-9
MW:	560.6 D

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LDC1267

Item number: TGM-T2311-100mg

Description: LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM). Target: TAM Receptor. Smiles: CCOc1cn(nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)-c1ccc(F)cc1C. References: Paolino M, et al. Nature. 2014, 507(7493), 508-512.

CAS	1361030-48-9
MW:	560.55 D

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