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Item number: Cay21756-1

Fidarestat is an aldose reductase inhibitor (IC50 = 0.026 µM using human recombinant enzyme) that also inhibits aldo-keto reductase family 1 member B10 (AKR1B10, IC50 = 33 µM using human recombinant enzyme). It decreases sorbitol and myo-inositol levels in the sciatic nerve of rats with diabetes induced by...

Keywords:	(2S,4S)-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
Application:	Aldose reductase inhibitor
CAS	136087-85-9
MW:	279.2 D

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Fidarestat

Item number: TGM-T15281-10mg

Description: Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 µM, and 1.8 µM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease. Target: Reductase. Smiles: NC(=O)[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(F)ccc2O1. References: Ruiz FX, et al. X-ray...

Keywords:	SNK 860
Application:	Targets aldehyde reductase [EC:1.1.1.21] (AKR1B)
CAS	136087-85-9
MW:	279.22 D

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