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Item number: TGM-T16848-1mg

Description: SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM). Target: PKC, Chk. Smiles:...

Application:	Chk1 inhibitor
CAS	135897-06-2
MW:	393.39 D

352.00€ *

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SB 218078

Item number: Cay13335-1

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 µM. SB 218078 releases G2 cell cycle arrest induced by gamma-irradiation or...

Keywords:	9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione
Application:	Chk1 inhibitor
CAS	135897-06-2
MW:	393.4 D

193.00€ *

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