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SPP 86
Item number: Cay37390-1
A RET inhibitor (IC50 = 0.008 µM), selective for RET over a panel of 44 serine/threonine/tyrosine kinases at 10 µM but does inhibit nine by >75%, selective for RET over a panel of 63 receptor and non-receptor tyrosine kinases 0.4 µM but does inhibit six, including RET, by >75%, reduces the proliferation of HCT116...
| Keywords: | 1-(1-methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Application: | RET inhibitor |
| CAS | 1357349-91-7 |
| MW: | 277.32 D |
From 38.00€
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SPP-86
Item number: TGM-T16923-100mg
Description: SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM. Target: c-RET. Smiles: CC(C)n1nc(C#Cc2ccccc2)c2c(N)ncnc12. References: Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer....
| CAS | 1357349-91-7 |
| MW: | 277.32 D |
From 39.00€
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