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AGI-5198
Item number: TGM-T2104-100mg
Description: AGI-5198 (IDH-C35) is a potent and selective inhibitor of IDH1 R132H and R132C mutants, with IC50 values of 0.07 µM and 0.16 µM, respectively. Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: Cc1nccn1CC(=O)N(C(C(=O)NC1CCCCC1)c1ccccc1C)c1cccc(F)c1. References: Rohle D, et al. Science,...
| Keywords: | IDH-C35 |
| CAS | 1355326-35-0 |
| MW: | 462.56 D |
From 31.00€
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AGI-5198
Item number: Cay14624-1
Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and NAD phosphate (NADP+)-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing a-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade...
| Keywords: | N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide |
| Application: | Inhibitor of IDH1 R132H and R132C mutants |
| CAS | 1355326-35-0 |
| MW: | 462.6 D |
From 128.00€
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AGI-5198
Item number: AG-CR1-3528-M005
Potent and selective inhibitor of IDH1 (isocitrate dehydrogenase 1) R132H and R132C mutants in vitro with IC50 values of 0.07 and 0.16µM, respectively. Does not inhibit wild-type IDH1 or any of the examined IDH2 isoforms (IC50>100µM). Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and...
| Keywords: | N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide, IDH-C35 |
| Application: | Potent, selective IDH1 (isocitrate dehydrogenase 1) R132H and R132C mutant inhibitor |
| CAS | 1355326-35-0 |
| MW: | 462.6 D |
From 99.00€
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