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AC-710
Item number: Cay29498-1
AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...
| Keywords: | N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy... |
| Application: | PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor |
| CAS | 1351522-04-7 |
| MW: | 562.7 D |
From 57.00€
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AC710
Item number: TGM-TQ0235-10mg
Description: AC710 is a potent PDGFR inhibitor with Kds of 0.6 nM for FLT3, 1 nM for KIT, 1.57 nM for CSF1R, 1.3 nM for PDGFRalpha, and 1 nM for PDGFRbeta. Target: c-Kit, FLT, PDGFR. Smiles: CCN1C(C)(C)CC(CC1(C)C)Oc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1. References: Liu G, et al. Discovery of AC710, a...
| Application: | PDGFR family kinase (c-Kit, FLT3, PDGFRbeta, CSF1R) inhibitor |
| CAS | 1351522-04-7 |
| MW: | 562.7 D |
From 37.00€
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