XL147 analog 2 is an analog of XL147 (Cay-18011).Formal Name: N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-benzamide. CAS Number: 1349796-36-6. Molecular Formula: C31H29N5O6S. Formula Weight: 599.7. Purity: >95%. Formulation: (Request formulation change), A...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

SAR245409 is a pyridopyrimidinone derivative that inhibits PI3K and mTOR. This compound exhibits anticancer chemotherapeutic activity and shows benefit in clinical trials as a potential treatment for advanced solid tumors. SAR245409 inhibits cell proliferation and tumor growth in a variety of cancer models.