Description: ML240 is a selective, ATP-competitive p97 inhibitor. Target: p97. Smiles: COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12. References: Tsui-Fen Chou et al. Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains.

ML-240 is an ATP-competitive inhibitor of the D2 domain of the ATPase p97 (IC50 = 0.11 µM, Ki = 0.22 µM). It disrupts the endoplasmic reticulum-associated degradation (ERAD) and autophagy pathways, preventing the degradation of p97-dependent proteasome substrates (IC50 = 0.9 µM) and causing accumulation of ubiquitin...