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Item number: Cay43541-10

ML-218 is an inhibitor of T-type voltage-gated calcium channel 3.2 (Cav3.2) and Cav3.3. It inhibits currents in whole-cell patch clamp assays using HEK293 cells expressing Cav3.2 or Cav3.3 (IC50s = 310 and 274 nM, respectively). ML-218 (0.1-30 mg/kg) decreases the latency to paw withdrawal in a rat model of...

Keywords:	3,5-dichloro-N-[[(1alpha,5alpha,6alpha)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide
Application:	Cav3.2 / Cav3.3 inhibitor
CAS	1346233-68-8
MW:	369.33 D

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ML218

Item number: TGM-T12076L-1mL

Description: ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN). Target: Calcium...

CAS	1346233-68-8
MW:	369.33 D

From 159.00€ *

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