Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).} Actinonin acts as an herbicide by targeting plastid peptide...

White crystal powder. A naturally occurring antibacterial agent that is a potent peptide deformylase (PDF) inhibitor. It has shown dose-dependent antitumor effects on AKR leukemia in vivo.

Synthetic. Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo...