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RKI-1447
RKI-1447

Item number: Cay16278-5

RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2...
Keywords: N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea
Application: ROCK inhibitor
CAS 1342278-01-6
MW: 326.4 D
From 92.00€ *
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RKI-1447
RKI-1447

Item number: LKT-R4132.1

ROCK1/2 inhibitor.
Keywords: RKI1447
Application: ROCK1/2 inhibitor
CAS 1342278-01-6
MW: 326.37 D
From 82.00€ *
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RKI-1447
RKI-1447

Item number: TGM-T1898-100mg

Description: RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. Target: ROCK. Smiles: Oc1cccc(CNC(=O)Nc2nc(cs2)-c2ccncc2)c1. References: Patel RA, et al. Cancer Res, 2012, 72(19), 5025-5034.
Keywords: RKI1447
Application: ROCK inhibitor
CAS 1342278-01-6
MW: 326.37 D
From 45.00€ *
Review