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Item number: TGM-T2654-100mg

Description: GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 kinases. Target: Autophagy, PERK, Apoptosis. Smiles: Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1. References: Atkins C, et al....

CAS	1337532-29-2
MW:	416.45 D

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GSK2656157

Item number: Cay17372-5

GSK2656157 is an inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, IC50 = 0.9 nM). It is selective for PERK over a panel of additional kinases. GSK2656157 blocks both stress-induced PERK autophosphorylation and eIF2alpha substrate phosphorylation and decreases levels of ATF4 and CHOP in...

Keywords:	1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone
Application:	PERK inhibitor
CAS	1337532-29-2
MW:	416.5 D

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