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GSK2193874
Item number: Cay17715-5
GSK2193874 is a potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively. It is selective for TRPV4 over ~200 other human receptors, channels, and enzymes. GSK2193874 is effective in...
| Keywords: | 3-([1,4'-bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
| Application: | TRPV4 antagonist |
| CAS | 1336960-13-4 |
| MW: | 691.6 D |
From 49.00€
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GSK2193874
Item number: TGM-T5640-100mg
Description: GSK2193874 was identified as a selective, orally active TRPV4 blocker. Target: TRP/TRPV Channel. Smiles: FC(F)(F)c1cccc(c1)-c1nc2cc(Br)ccc2c(C(=O)NC2(CC2)c2ccccc2)c1CN1CCC(CC1)N1CCCCC1. References: Cheung M , Bao W , Behm D J , et al. Discovery of GSK2193874: An Orally Active, Potent, and Selective...
| Application: | TRPV4 antagonist |
| CAS | 1336960-13-4 |
| MW: | 691.62 D |
From 35.00€
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