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Item number: Cay10010311-5

Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...

Keywords:	Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Application:	JAK2 inhibitor
CAS	133550-30-8
MW:	294.3 D

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AG490

Item number: TGM-T2600-100mg

Description: AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 µM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src. Target: Autophagy, EGFR, JAK, STAT. Smiles: C(=C(/C(NCC1=CC=CC=C1)=O)\C#N)\C2=CC(O)=C(O)C=C2. References: Gazit A, et al....

Keywords:	Zinc02557947, AG-490, Tyrphostin B42, Tyrphostin AG 490, AG 490
Application:	JAK2 inhibitor
CAS	133550-30-8
MW:	294.3 D

From 41.00€ *

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