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gamma-Secretase Inhibitor I
Item number: Cay45205-1
A gamma-secretase and proteosome inhibitor, reduces growth of BT474, T47D, SK-BR-3, and MDA-MB-468 breast cancer cells (ED50s = 2.5, 2.4, 1.6, and 1.4 µM, respectively), decreases the levels of N1ICD in the same cells, reduces proteasome activity in MCF-7 and MDA-MB-231 cells from 1-4 µM. SMILES:...
| Keywords: | GSI-I, Z-Leu-Leu-Nle-CHO, Z-LLNle-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide |
| Application: | Gamma-secretase, proteasome inhibitor |
| CAS | 133407-83-7 |
| MW: | 475.63 D |
From 83.00€
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Z-LLNle-CHO
Item number: TGM-T29233-100mg
Description: Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. Smiles: [C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@@H](CCCC)C=O)=O)CC(C)C. References: Ikezawa Y,...
| CAS | 133407-83-7 |
| MW: | 475.62 D |
From 1,440.00€
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