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Item number: Cay11084-10

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.Formal Name:...

Keywords:	N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)...
Application:	Potent, selective EHMT1 / EHMT2 inhibitor
CAS	1320288-19-4
MW:	635.9 D

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UNC 0631

Item number: TGM-T2354-100mg

Description: UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM). Target: Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(CC4CCCCC4)CC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C. References: Liu F, et al. J Med Chem. 2011, 54(17), 6139-6150.

Keywords:	UNC0631
CAS	1320288-19-4
MW:	635.93 D

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