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Item number: TGM-TQ0232-100mg

Description: UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 µM in MCF7...

Keywords:	UNC 0646
Application:	Potent, selective EHMT1 / EHMT2 inhibitor
CAS	1320288-17-2
MW:	621.9 D

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UNC0646

Item number: Cay11085-1

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM,...

Keywords:	N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]...
Application:	Potent, selective EHMT1 / EHMT2 inhibitor
CAS	1320288-17-2
MW:	621.9 D

From 66.00€ *

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