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NVP-CGM097
Item number: TGM-TQ0231-100mg
Description: NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2). Target: E1/E2/E3 Enzyme, Mdm2. Smiles: COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1. References: Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative...
| Keywords: | CGM097 |
| Application: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1313363-54-0 |
| MW: | 659.26 D |
From 79.00€
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NVP-CGM097
Item number: Cay29519-1
NVP-CGM097 is an inhibitor of the protein-protein interaction between murine double minute 2 (MDM2) and p53 (IC50 = 1.7 nM for human MDM2 in a TR-FRET assay). It is selective for human MDM2 (Ki = 1.3 nM) over dog, mouse, and rat Mdm2 (Kis = 20.5, 65.9, and 47.4 nM, respectively). NVP-CGM097 selectively inhibits...
| Keywords: | (1S)-1-(4-chlorophenyl)-1,4-dihydro-6-methoxy-7-(1-methylethoxy)-2-[4-[methyl[[trans-4-(4-methyl-3-oxo-1-piperazinyl)cyclo... |
| Application: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1313363-54-0 |
| MW: | 659.3 D |
From 128.00€
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