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Nifekalant (hydrochloride)
Item number: Cay20997-1
Nifekalant is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed rectifier potassium channel (IKr, IC50 = 10 µM) and prolongs cardiac action potential duration (APD) in isolated dog Purkinje fibers when used at concentrations of 1 and 3 µg/ml. Nifekalant (3 mg/kg) inhibits arrhythmias...
| Keywords: | 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, monohydrochloride |
| Application: | Ikr blocker |
| CAS | 130656-51-8 |
| MW: | 441.9 D |
From 49.00€
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Nifekalant hydrochloride
Item number: LKT-N3422.10
A class III antiarrhythmic drug. It has been shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage-dependent and frequency-dependent manner.
| Keywords: | MS 551 |
| Application: | HERG channel inhibitor |
| CAS | 130656-51-8 |
| MW: | 441,91 D |
From 136.00€
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Nifekalant hydrochloride
Item number: TGM-T2712-10mg
Description: Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM. It is a Class III antiarrhythmic compound and can be used in the study of tachyarrhythmias. Target: Potassium Channel. Smiles: Cl.Cn1c(NCCN(CCO)CCCc2ccc(cc2)[N+]([O-])=O)cc(=O)n(C)c1=O. References: Oyabe A, Sano H....
| Application: | Targets potassium voltage-gated channel Shal-related subfamily D member 3 (KCND3, KV4.3) |
| CAS | 130656-51-8 |
| MW: | 441.91 D |
From 60.00€
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