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Item number: TGM-T16294-100mg

Description: NGP555 is a modulator of gamma-secretase. Target: Gamma-secretase. Smiles: CCc1cc(Nc2nc(cs2)-c2ccc(c(F)c2)-n2cnc(C)c2)c(C)cc1C. References: Kounnas MZ, et al. NGP 555, a gamma-Secretase Modulator, Lowers the Amyloid Biomarker, Abeta42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease...

Application:	gamma-secretase modulator
CAS	1304630-27-0
MW:	406.52 D

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NGP-555

Item number: Cay27918-1

NGP-555 is a modulator of gamma-secretase that inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta, IC50s = 531 and 131 nM for Abeta40 and Abeta42, respectively, in HeLa cell membranes). It is selective for AICD cleavage to Abeta over E-cadherin and Notch cleavage to their signaling...

Keywords:	N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolamine
Application:	gamma-secretase modulator
CAS	1304630-27-0
MW:	406.5 D

From 161.00€ *

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