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Item number: Cay30140-10

MSA-2 is an agonist of stimulator of interferon genes (STING). It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively) and induces secretion of IFN-beta from THP-1 cells by 129% relative to induction by 2'3'-cGAMP (Cay-19887) when used at a...

Keywords:	5,6-dimethoxy-gamma-oxo-benzo[b]thiophene-2-Butanoic Acid
Application:	STING agonist
CAS	129425-81-6
MW:	294.3 D

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MSA-2

Item number: AG-CR1-0164-M001

MSA-2 is a new orally available non-nucleotide STING (STimulator of INterferon Genes) agonist, with EC50s of 8.3 and 24µM for human STING isoforms WT and HAQ. Activation of the STING protein by its natural ligand, cyclic guanosine monophosphate-adenosine monophosphate (cGAMP, a cytosolic double-stranded DNA sensor),...

CAS	129425-81-6

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