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Nirogacestat
Item number: TGM-T6935-10mg
Description: Nirogacestat (PF 03084014) is a specific gamma-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). Target: Apoptosis, Gamma-secretase. Smiles: CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(cn1)C(C)(C)CNCC(C)(C)C. References: Wei P, et al. Mol Cancer Ther, 2010, 9(6), 1618-1628.
| Keywords: | PF 03084014, PF03084014, PF-3084014, PF-03084014 |
| Application: | Antineoplastic, gamma-Secretase inhibitor |
| CAS | 1290543-63-3 |
| MW: | 489.64 D |
From 34.00€
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PF-3084014
Item number: Cay27061-1
PF-3084014 is a gamma-secretase inhibitor (IC50s = 6.2 and 1.2 nM in an enzyme assay and in whole cells, respectively). It inhibits gamma-secretase activity without inducing Notch-related toxicity (EC50s = 1,300-3,000 nM for B cells in fetal thymic organ cultures). It reduces the level of amyloid-beta (1-40)...
| Keywords: | (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]... |
| Application: | gamma-secretase inhibitor |
| CAS | 1290543-63-3 |
| MW: | 489.6 D |
From 44.00€
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