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FRAX597
Item number: TGM-T6014-1mg
Description: FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM). Target: PAK. Smiles: CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O. References: Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114.
| Application: | p21-activated kinase inhibitor |
| CAS | 1286739-19-2 |
| MW: | 558.1 D |
From 34.00€
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FRAX597
Item number: Cay22205-1
FRAX597 is an inhibitor of p21-activated kinase (PAK) that is selective for group I PAKs (IC50s = 7.7, 12.8, and 19.3 nM for PAK 1, 2, and 3, respectively) over group II PAKs (IC50 > 10 µM for PAK4 and 50 = 70 nM), prevents proliferation of transformed Schwann cells by halting the cell cycle in the G1 phase, and...
| Keywords: | 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Application: | p21-activated kinase inhibitor |
| CAS | 1286739-19-2 |
| MW: | 558.1 D |
From 53.00€
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