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Item number: Cay22205-1

FRAX597 is an inhibitor of p21-activated kinase (PAK) that is selective for group I PAKs (IC50s = 7.7, 12.8, and 19.3 nM for PAK 1, 2, and 3, respectively) over group II PAKs (IC50 > 10 µM for PAK4 and 50 = 70 nM), prevents proliferation of transformed Schwann cells by halting the cell cycle in the G1 phase, and...

Keywords:	6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one
Application:	p21-activated kinase inhibitor
CAS	1286739-19-2
MW:	558.1 D

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