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PF-4989216
Item number: Cay19308-1
PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110alpha, p110beta, p110gamma, p110delta, and VPS34, respectively). It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and...
| Keywords: | 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile |
| Application: | PI3K inhibitor |
| CAS | 1276553-09-3 |
| MW: | 380.4 D |
From 69.00€
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PF-4989216
Item number: TGM-T6938-100mg
Description: PF-4989216 is a potent and selective PI3K inhibitor with IC50 values of 2 nM (p110alpha), 142 nM (p110beta), 65 nM (p110gamma), 1 nM (p110delta), and 110 nM (VPS34). Target: Apoptosis, PI3K. Smiles: Fc1cc(ccc1-c1c(sc(N2CCOCC2)c1C#N)-c1ncn[nH]1)C#N. References: Walls M, et al. Clin Cancer Res. 2014,...
| Keywords: | PF 4989216 |
| Application: | PI3K inhibitor |
| CAS | 1276553-09-3 |
| MW: | 380.4 D |
From 32.00€
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