NHI 2 is an inhibitor of lactate dehydrogenase A (LDHA, IC50 = 14.7 µM). It is selective for LDHA over LDHB (IC50 = 55.8 µM). It inhibits lactate production in HeLa cells when used at concentrations of 100 and 200 µM. NHI 2 is cytotoxic to HeLa cells (IC50 = 33.4 µM).Formal Name:...

Description: NHI-2 is a lactate dehydrogenase A (LDHA) inhibitor with an IC50 value of 14.7 µM, demonstrating high selectivity for LDHA over LDHB, for which the IC50 is 55.8 µM. NHI-2 functions as an efficient anti-glycolytic agent, enhancing apoptosis, inducing cell cycle arrest at the S and G2 phases, and exerting...