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Item number: Cay33785-1

Enarodustat is a pan hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (Kis = 16, 61, and 101 nM for HIF-PH1, -2, and -3, respectively). It increases erythropoietin (EPO) levels in Hep3B cells (EC50 = 4.7 µM). Enarodustat (3 mg/kg) increases plasma EPO levels in control rats, as well as plasma EPO and...

Keywords:	JTZ-951, N-[[7-hydroxy-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl]-glycine
Application:	Pan HIF-PH inhibitor
CAS	1262132-81-9
MW:	340.3 D

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Enarodustat

Item number: TGM-T15219-100mg

Description: Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 µM) and has the potential for renal anemia treatment. Target: HIF/HIF Prolyl-Hydroxylase, Others. Smiles: OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12. References: Ogoshi Y, et al. Discovery of JTZ-951: A HIF...

Keywords:	JTZ-951
Application:	Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH)
CAS	1262132-81-9
MW:	340.33 D

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