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GS-444217
Item number: TGM-T5190-100mg
Description: GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM). Target: ASK, Apoptosis, MAPK. Smiles: O=C(Nc1cccc(c1)-c1nncn1C1CC1)c1cc(ccn1)-n1cnc(c1)C1CC1. References: Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney...
| Keywords: | GS444217, GS 444217 |
| Application: | AKS1 (MEKK5) inhibitor |
| CAS | 1262041-49-5 |
| MW: | 411.46 D |
From 42.00€
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GS-444217
Item number: Cay40757-10
GS-444217 is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 2.87 nM). It is selective for ASK1 over 442 additional kinases at 1 µM. GS-444217 (0.001-10 µM) inhibits phosphorylation of the ASK1 substrates MAP kinase kinase 3 (MKK3), MKK6, and MKK4, as well as their downstream substrates p38 MAPK...
| Keywords: | Apoptosis Signal-regulating Kinase 1 Inhibitor 1, Apoptosis Signal-regulating Kinase 1-IN-1, ASK1 Inhibitor 1, ASK1-IN-1,... |
| Application: | AKS1 (MEKK5) inhibitor |
| CAS | 1262041-49-5 |
| MW: | 411.5 D |
From 108.00€
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