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Item number: Cay43908-10

Mitapivat is an allosteric activator of erythrocyte pyruvate kinase (PKR). It increases PKR activity and ATP levels in red blood cells isolated from patients with pyruvate kinase deficiency when used at a concentration of 10 µM. Mitapivat increases hematocrit and hemoglobin levels, decreases osmotic fragility, and...

Keywords:	AG-348
Application:	Allosteric pyruvate kinase PKLR activator
CAS	1260075-17-9
MW:	450.56 D

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Mitapivat

Item number: TGM-T4223-100mg

Description: Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency. Target: PKM. Smiles: O=C(N1CCN(CC2CC2)CC1)c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1. References: C Kung. Activators of pyruvate kinase M2 and methods of...

Keywords:	PKR-IN-1
CAS	1260075-17-9
MW:	450.55 D

From 33.00€ *

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