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AMG 511
Item number: TGM-T14214-10mg
Description: AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks (Kis of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kalpha, beta, delta, and gamma, respectively), exhibiting anti-tumor activity in a mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling as indicated by a...
| CAS | 1253573-53-3 |
| MW: | 517.58 D |
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AMG 511
Item number: Cay41853-1
An inhibitor of class I PI3Ks, selective for PI3K over 372 other protein kinases at 1 µM, inhibits Akt phosphorylation in U87MG cells (IC50 = 4 nM), reduces tumor growth in a U87MG mouse xenograft model at doses of 1, 3, and 10 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | 4-[2-[(5-fluoro-6-methoxy-3-pyridinyl)amino]-5-[(1R)-1-[4-(methylsulfonyl)-1-piperazinyl]ethyl]-3-pyridinyl]-6-methyl-1,3,... |
| Application: | Class I PI3K inhibitor |
| CAS | 1253573-53-3 |
| MW: | 517.58 D |
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