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Item number: Cay17003-1

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal...

Keywords:	AGN-PC-0D106I, 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Application:	Cell-permeable Mdm2 inhibitor
CAS	1253491-42-7
MW:	324.4 D

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SP-141

Item number: TGM-T21773-100mg

Description: SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. Target: Mdm2. Smiles: COc1ccc2[nH]c3c(nccc3c2c1)-c1cccc2ccccc12. References: Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer...

Keywords:	SP 141
CAS	1253491-42-7
MW:	324.38 D

From 37.00€ *

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