Yellow-white amorphous powder. A chemotherapeutic agent effective against a number of solid tumors including non- small-cell carcinoma, advanced prostatic carcinoma, breast cancer, head and neck cancer, and Hodgkin's lymphoma. It induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells.

Vinorelbine is a semisynthetic vinca alkaloid with microtubule destabilizing activity. It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM. In in vitro and in vivo models, vinorelbine has demonstrated...