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SPI 112Me
Item number: Cay36819-1
A prodrug form of SPI 112, inhibits the PTP activity of SHP-2E76K in TK-1 cells, inhibits Paxillin dephosphorylation, ERK1/2 activation, and cell migration in EGF-stimulated MDA-MB-468 cells at 20 µM. SMILES: COC(C1=CC=CC(N/N=C2C3=CC(S(NCC4=CC=C(C=C4)F)(=O)=O)=CC=C3NC/2=O)=C1)=O. InChi Code:...
| Keywords: | 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-benzoic acid,... |
| Application: | SPI 112 prodrug, SHP-2 protein tyrosine phosphatase inhibitor |
| CAS | 1243685-62-2 |
| MW: | 482.49 D |
From 42.00€
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SPI--112Me
Item number: TGM-T4627-100mg
Description: SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays. Target: Others. Smiles: N(\NC1=CC(C(OC)=O)=CC=C1)=C\2/C=3C(NC2=O)=CC=C(S(NCC4=CC=C(F)C=C4)(=O)=O)C3. References: Win-Piazza, H., Schneeberger, V., Chen, L.,...
| CAS | 1243685-62-2 |
| MW: | 482.48 D |
From 39.00€
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