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XMD8-92
Item number: Cay19173-10
XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively) in a panel of 402 kinases. It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic leukemia protein (PML), and PML-dependent activation of p21. XMD8-92...
| Keywords: | 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Application: | ERK5 inhibitor |
| CAS | 1234480-50-2 |
| MW: | 474.6 D |
From 49.00€
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XMD8-92
Item number: TGM-T1843-100mg
Description: XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM). Target: Epigenetic Reader Domain, ERK, BMI-1. Smiles: CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCC(O)CC1. References: Yang Q, et al. Cancer Cell. 2010, 18(3), 258-267.
| Application: | ERK5 inhibitor |
| CAS | 1234480-50-2 |
| MW: | 474.55 D |
From 46.00€
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