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XMD8-87
Item number: Cay23354-1
XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 µM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and 50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50...
| Keywords: | 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Application: | TNK2 inhibitor |
| CAS | 1234480-46-6 |
| MW: | 445.5 D |
From 49.00€
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XMD8-87
Item number: TGM-T3709-100mg
Description: XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types. Target: Tyrosinase, PPAR. Smiles: COc1cc(ccc1Nc1ncc2NC(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1....
| Keywords: | ACK1-B19 |
| Application: | TNK2 inhibitor |
| CAS | 1234480-46-6 |
| MW: | 445.52 D |
From 38.00€
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